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Note: *equal contribution. #: corresponding author

Representative media reports:

45. Meah, A., Vedarethinam, V., Bronstein, R., Gujarati, N., Jain, T., Mallipattu, S.K., Li, Y., and Wang, J.# Single-Cell Spatial MIST for Versatile, Scalable Detection of Protein Markers. Biosensors, (2023), 13(852). DOI: 10.3390/bios13090852 

HighlightWe developed a single-cell spatial MIST technology to detect 1 to 125 biomarkers on kidney and brain tissue sections.

single cell spatial MIST.png

44. Yang, LW, Dutta, P., Davuluri, R.V., and Wang, J.Rapid, High-Throughput Single-Cell Multiplex In Situ Tagging (MIST) Analysis of Immunological Disease with Machine Learning. Analytical Chemistry, (2023), 95(19), 7779-7787. DOI:10.1021/acs.analchem.3c01157

HighlightWe used 46-plex single-cell functional proteome and machine learning to diagnose immunological disorders.


43. Yang, LW, Ball, A., Liu, J., Jain, T., Li, YM, Akhter F., Zhu, DH, and Wang, J.Cyclic Microchip Assay for Measurement of Hundreds of Functional Proteins in Single Neurons. Nature Communications, (2022), 13, 3548. DOI:10.1038/s41467-022-31336-x

Highlight: ~200 protein markers are analyzed in single brain cells.


42. Yang, LW, Liu, J., Reddy, R. and Wang, J.Single-Cell Proteomics Study of Immune Cell Diversity by Quantitating 465 Proteins. BioRxiv, (2022). DOI:10.1101/2022.01.07.475463

Highlight: The highest multiplexed assay of proteins in single cells.

Picture 4_edited.jpg

41. Reddy, R.*, Yang, LW,* Liu, J., Liu, ZJ and Wang, J.Spatial MIST Technology for Rapid, Highly Multiplexed Detection of Protein Distribution on Brain Tissue. Analytical Chemistry, (2022), 94(9), 3922-3929. DOI:10.1021/acs.analchem.1c04970 (*: equal contribution)

Highlight: 5 min multiplexed detection of dozens of protein markers of solid tissue.


40. Abdullah, M.A.A.,* Nooshin, A.,* Yang, LW, Paluh, J.L.# and Wang, J.Multiplexed analysis of neural cytokine signaling by a novel neural cell–cell interaction microchip. Lab on a Chip, (2020), 20. DOI:10.1039/D0LC00401D. (*: equal contribution; IF: 6.9)

ma paper.tif

38. Yang, L.W., George, J. and Wang, J.Deep Profiling of Cellular Heterogeneity by Emerging Single‐Cell Proteomic Technologies. Proteomics, (2019), 1900226. DOI: 10.1002/pmic.201900226. (IF: 3.1)

37. Dai, Y.W., Weng, J.P., George, J., Chen, H., Lin, Q.S., Wang, J., Royzen, M., and Zhang, Q. Three-Component Protein Modification Using Mercaptobenzaldehyde Derivatives. Organic Letters, (2019), 21(10), 3828-3833. DOI: 10.1021/acs.orglett.9b01294. (IF: 6.5)


36. Abdullah, M.A.A and Wang, J.Ultrasimple Single-Cell Detection of Multiple Cytokines by a Nanowell Chip Integrated with Encoded Microarrays. ACS Sensors, (2019), 4(9). DOI: 10.1021/acssensors.9b00765. (IF: 6.9)

Sirsendu paper.jpg

35. Bhowmick, S. and Wang, J.Microchip cytometry for multiplexed single-cell protein detection in a low-resource setting toward point of care diagnosis. ACS Sensors, (2018), 3(12). DOI: 10.1021/acssensors.8b01015. (IF: 6.9)

Advanced Science 2018.png

33. Zhao, P., George, J., Li, B., Amini, N., Paluh, J., and Wang, J.# Clickable Multifunctional Dumbbell Particles for in Situ Multiplex Single-Cell Cytokine Detection. ACS Applied Materials & Interfaces, (2017). DOI: 10.1021/acsami.7b08338. (IF: 8.5)

32. George, J. and Wang, J.Assay of Genome-Wide Transcriptome and Secreted Proteins on the Same Single Immune Cells by Microfluidics and RNA Sequencing. Analytical Chemistry, (2016), 88(20). DOI: 10.1021/acs.analchem.6b03214. (IF: 6.3)

31. Wang, J.#, Egnot, B.,** and Paluh, J. Cell Competition and Cooperation in Tissue Development. Journal of Tissue Science & Engineering, (2016), 7(2). DOI: 10.4172/2157-7552.100e130. (Invited) (** undergraduate)

30. Wang, J.# and Yang, F. Emerging Single-Cell Technologies for Functional Proteomics in Oncology. Expert Review in Proteomics, (2016), 13(9). DOI: 10.1080/14789450.2016.1215920. (Invited)

29. Ramirez, L., Herschkowitz, J., and Wang, J.# Stand-Sit Microchip for High-Throughput, Multiplexed Analysis of Single Cancer Cells. Scientific Reports, (2016), 6(32505). DOI: 10.1038/srep32505.

28. Li, B., He, MH, Ramirez, L.S., George, J.,** and Wang, J.# Multifunctional Hydrogel Microparticles by Polymer-Assisted Photolithography. ACS Applied Materials & Interfaces, (2016), 8 (6). DOI: 10.1021/acsami.5b11883. (** undergraduate)

27.  Ramirez, L.S.,* He, MH,* Mailloux, S., George, J.,** and Wang, J.# Facile and High-Throughput Synthsis of Functional Microparticles with Quick Response (QR) Code. Small, (2016), 12(24). DOI: 10.1002/smll.201670118. (*co-first author) (**undergradaute)

- Highlighted as very urgent and very imporant paper

- Frontispiece article

- Big Problem, Tiny Answer (UAlbany news)

- Fighting Facke Pharmaceuticals with Tiny, Edible Bar Codes. ( Smithsonian Magizine)

26. Mailloux, S., Ramirez, L.S., and Wang, J.# Microfluidic Single-Cell Functional Proteomics. In the book Microfluidic Methods for Molecular Biology. Springer, 2015, ISBN 978-3-319-30017-7.

25. Ramirez, L.S. and Wang, J.# Flow-Pattern Guided Fabrication of High-Density Barcode Antibody MicroarrayJournal of Visualized Experiments, (2015), e53644. DOI: 10.3791/53644. (Invited article)

Before 2014 (Caltech and Purdue University)

24.  Wang, J.*, Kravchenko-Balasha, N.*, Levine, R. D, Heath, J. R. Glioblastoma cellular architectures are predicted through knowledge of two-cell interactions. Proceedings of National Academy of Sciences 111(2014) 6521-6526. (IF=9.7; *co-first author)

23. Nathanson, D., Gini, B., Mottahedeh, J., Visnyei, K., Koga, T., Gomez, G., Eskin, A., Hwang, K., Wang, J., et al. Targeted therapy resistance mediated by dynamic regulation of extrachromosomal mutant EGFR DNA. Science, 343(2014) 72-76. (IF=31.0)

22. Wei, W., Shin, Y. S., Ma, C., Wang, J., Elitas, M., Fan, R., Heath, J.R. Microchip platforms for multiplex single-cell functional proteomics with applications to immunology and cancer research. Genome Medicine, 5(2013) 75-81. (IF=3.9)

21. Dooraghi, A. A., Vu, N. T., Silverman, R. W., Farrell, R., Shah, K. S., Wang, J., Heath, J. R. and Chatziioannou, A. F. Betabox: a beta particle imaging system based on a position sensitive avalanche photodiode.  Physics in Medicine and Biology, 58(2013) 3739-3753. (IF=2.8)

20. Wang, J., Tham, D., Ahmad, H., Ma, C., Yu, J.-K., Heath, J. R. Quantitating cell-cell interaction functions, with applications to glioblastoma multiforme cancer cells. Nano Letters, 12(2012) 6101-6106. (IF=13.1)

     - "Listen to Cancer Cell chat" Chemical & Engineering News (November,2012).

19. Wang, J., Kwang, K.W., Brass, D., Radu, C., Christofk, H., Phelps, M., Heath, J. R. Fast metabolic response to drug intervention through analysis on a miniaturized, highly integrated molecular imaging system. Journal of Nuclear Medicine, 54(2013) 1820-1824.  (IF=6.4)

18.   Zhan, Y., Cao, Z., Bao, N., Li, J., Wang, J., Geng, T., Lin, H., Lu, C. Low-frequency ac electroporation shows strong frequency dependence and yields comparable transfection results to dc electroporation. Journal of Controlled Release 160 (2012) 570-576. (IF=6.5)

17. Wang, J.*, Zhan, Y.*, Bao, N., Lu, C. Quantitative measurement of quantum dot uptake at the cell population level using microfluidic evanescent-wave-based flow cytometry. Lab on a Chip, 12 (2012) 1441-1445. (IF=6.3; * co-first author)

    - Cover article in Issue 8 of Lab on a Chip.

16.  Geng, T., Zhan, Y., Wang, J., Lu, C. Transfection of cells using flow-through electroporation based on constant voltage. Nature Protocols 6 (2011) 1192-1208. (IF=9.9)

15.  Vermesh, U*., Vermesh, O.*, Wang, J., Kwong, G. A., Ma, C., Hwang, K., Heath, J. R. High-density, multiplexed patterning of cells at single-cell resolution for tissue engineering and other applications. Angewandte Chemie International Edition 32 (2011) 7378-7380. (IF=13.5)

14. Wang, J., Ahmad, H., Ma, C., Shi, Q. -H., Vermesh, O., Vermesh, U. and Heath, J. R. A self-powered, one-step chip for rapid, quantitative and multiplexed detection of proteins from pinpricks of whole blood. Lab on a Chip 10 (2010) 3157-3162. (IF=6.3)

13. Wang, J., Zhan, Y., Ugaz, V. M and Lu, C. Vortex-assisted DNA delivery.  Lab on a Chip 10 (2010) 2057-2061. (IF=6.3)

    - Cover article in Issue 16 of Lab on a Chip.

    - "Biotechnology: Swirling cells."  Nature (Vol 466, July 8 2010, page 163)

12. Wang, J., Fei, B., Zhan, Y., Geahlen, R. L. and Lu, C. Kinetics of NF-kappaB nucleocytoplasmic transport probed by single-cell screening without imaging. Lab on a Chip 10 (2010) 2911-2916. (IF=6.3)

11. Wang, J., Fei, B., Geahlen, R. L. and Lu, C. Quantitative analysis of protein translocations by microfluidic total internal reflection fluorescence flow cytometry. Lab on a Chip 10 (2010) 2673-2679. (IF=6.3)

10.  Zhan, Y., Wang, J., Bao, N., and Lu, C. Electroporation of cells in microfluidic droplets. Analytical Chemistry 81 (2009) 2027-2031. (IF=5.8)

9.  Wang, J., Bao, N., Paris, L. L., Geahlen, R. L. and Lu, C. Total internal reflection fluorescence flow cytometry. Analytical Chemistry 80 (2008) 9840-9844. (IF=5.8)

8.  Wang, J., Bao, N., Paris, L. L., Wang, H. -Y., Geahlen, R. L. and Lu, C. Detection of kinase translocation using microfluidic electroporative flow cytometry. Analytical Chemistry 80 (2008) 1087-1093. (IF=5.8)

7.  Bao, N., Wang, J. and Lu, C. Recent advances in electric analysis of cells in microfluidic systems. (Invited review) Analytical and Bioanalytical Chemistry 391 (2008) 933-942. (IF=3.8)

6.  Bao, N., Wang, J. and Lu, C. Microfluidic electroporation for selective release of intracellular molecules at the single cell level. Electrophoresis 29 (2008) 2939-2944. (IF=3.3)

5.  Wang, F., Wang, H., Wang, J., Wang, H. Y., Rummel, P. L., Garimella, S. V. and Lu, C. Microfluidic delivery of small molecules into mammalian cells based on hydrodynamic focusing. Biotechnology and Bioengineering 100 (2008) 150-158. (IF=3.9)

    -  Selected as the cover article (Vol.100 Issue 1).

4.  Wang, J., Stine, M. J. and Lu, C. Microfluidic cell electroporation using a mechanical valve. Analytical Chemistry 79 (2007) 9584-9587. (IF=5.8)

3.  Wang, J. and Lu, C. Single molecule λ-DNA stretching studied by microfluidics and single particle tracking. Journal of Applied Physics 102 (2007) 074703. (IF=2.2)

2.  Wang, J. and Lu, C. Microfluidic cell fusion under continuous direct current voltage. Applied Physics Letters 89 (2006) 234102. (IF=3.8)

1.  Wang, J., Xu, Z. -N.# , Shen, W. -H. and Cen, P. -L. Study on the extraction equilibrium of tilmicosin between aqueous and butyl acetate phases. Chemical Engineering Communications, 193 (2006) 427-437. (# professor; IF=0.9)

     * Equal contribution; IF: impact factor


Book chapter


Lu, C.†, Wang, J., Bao, N., Wang, H.Y. Electroporative flow cytometry for single cell analysis. Chemical Cytometry: Ultrasensitive analysis of single cells, Wiley-VCH, Weinheim, Germany, 2009. († Editor)


Patent applications


6.   Wang, J., Li, B. Polymer Assistant Photolithography for fabrication of multifunctional Hydrogel Microparticles. Patent disclosure, 2016.

5.   Wang, J., Mailloux, S., He, MH. High-throughput production of multifunctional suspension microarrays by massive coding of dissociated elements. Patent disclosure, 2015.

4.   Wang, J., Heath, J. R. An integrated PET microchip for radioassay. Provisional patent application, 2013.

3.   Wang, J., Heath, J.R. A lateral flow microfluidic assaying device and related method. US patent 8,586,348.

2.   Lu, C., Wang, J., Bao, N. and Geahlen, R.L. Electroporative flow cytometry. PCT application (WO2009032827), Sept. 2008; US patent pending (12/716,974), April, 2010.

1.   Lu, C., Wang, H.Y. and Wang, J. Fluidic device. US patent pending (11/583,535), Oct. 2006.

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